Use of Metallothionein-Transgenic and Null Mice to Determine the Role of Metallothionein in Cadmium Toxicity

  • Published : 2002.11.01

Abstract

Acute Cd exposure produces hepatotoxicity, whereas chronic Cd exposure produces nephrotoxicity, hematotoxicity, immunotoxicity and bone damage. Previous experiments suggest that the low-molecular-weight, metal-binding protein metallothionein (MT) in liver protects against liver injury, but is responsible for the kidney injury observed after chronic Cd exposure.(omitted)

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