Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
- /
- Pages.117-117
- /
- 2002
TOXICITY TESTS OF A NOVEL SOLUBILIZER FOR PACLITAXEL IN MALE BEAGLE DOGS
- Kim, Yeo-Woon (College of Pharmacy, Ewha Womans University) ;
- Min, Kyung-Nan (College of Pharmacy, Ewha Womans University) ;
- Syrie Pang (College of Pharmacy, Ewha Womans University) ;
- Song, Hae-Won (College of Pharmacy, Ewha Womans University) ;
- Lee, Min-Jae (College of Medicine, Seoul National University) ;
- Lee, Mi-Suk (College of Medicine, Seoul National University) ;
- Kim, Jong-Jae (College of Medicine, Seoul National University) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- Published : 2002.05.01
Abstract
Paclitaxel isolated from the pacific yew tree, Taxus brevifolia, is microtuble-stabilizing agent that has a promising anticancer activity against a wide variety of tumors such as ovarian, breast and lung cancers. Because of its poor water solubility, paclitaxel is currently formulated in a mixture of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) and dehydrated ethanol USP (1:1 v/v).(omitted)