Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.111-111
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- 2002
INCREASE OF INTRACELLULAR $CA^{2+}$ AND CYTOTOXICITY INDUCED BY NEURO-TOXICANTS IN PC12 CELLS CARRYING MUTANT PRESENILIN-2
- Shin, Im-Chul (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
- Hwang, In-Young (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
- Song, Youn-Sook (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
- Park, Cheol-Beom (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
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Oh, Ki-Wan
(Department of Pharmacy, College of Pharmacy, Chungbuk National University)
;
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Lee, Myung-Koo
(Department of Pharmacy, College of Pharmacy, Chungbuk National University)
;
- Kim, Young-Kyu (National Institute of Toxicological Research, KFDA) ;
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Hong, Jin-Tae
(Department of Pharmacy, College of Pharmacy, Chungbuk National University)
- Published : 2002.05.01
Abstract
Many cases of early onset autosomal dominant inherited forms of Alzheimer's disease (AD) are caused by mutation in the genes encoding presenilin-2 (PS-2) on chromosome 1. It is characterized by amyloid deposition and associated with loss of neuron. However, molecular mechanisms underlying the role of PS-2 mutation in the pathogenic AD are not known.(omitted)