Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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15-DEOXY-$\Delta$12,14-PROSTAGLANDIN J2 DECREASED ACTIVATION OF TRANSCRIPTION FACTOR NF-$\textsc{k}$B BY BETA-AMYLOID IN MUTANT PS-2 TRANSFECTED PC12 CELLS

  • Oh, Jae-Ho (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Hong, Jin-Tae (College of Pharmacy, Chungbuk National University) ;
  • Kim, Yong-Soon (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Youg-Kyu (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Ki-Sook (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Song, Chi-Won (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Hai-Kwan (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Chang-Won (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Jung, Kyung-Mi (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Yang, Ki-Hwa (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Chung, Soo-Youn (National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2002.05.01
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Abstract

Mutations in the presenilin genes (PS-1 and PS-2) are linked to early onset familial Alzheimer's disease(AD), but its underlying cellular mechanisms have not been clear. 15-Deoxy-Δ12, 14-prostaglandin J2 (15-deoxy-PGJ2) is know as a naturally occurring ligand of the peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$).(omitted)

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