Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.100-100
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- 2002
INHIBITION OF LPS-INDUCED p38 ACTIVATION AND iNOS EXPRESSION BY 2-AMINO-3-METHYLIMIDAZO[4,5-f]QUINOLINE
Abstract
2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a heterocyclic amine, significantly inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages. The decrease in NO production was found to correlate well with a decrease in iNOS mRNA expression as demonstrated by Northern blot analysis.(omitted)