한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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- Pages.97-97
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- 2002
EVALUATION OF CELL PROLIFERATION IN EAR AND LYMPH NODE USING BRDU IMMUNOHISTOCHEMISTRY FOR MOUSE EAR SWELLING TEST
- Lee, Jong-Kwon (National Institute of Toxicological Research, KFDA) ;
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Park, Jae-Hyun
(National Institute of Toxicological Research, KFDA)
;
- Kim, Hyung-Soo (National Institute of Toxicological Research, KFDA) ;
- Jung, Seung-Tae (National Institute of Toxicological Research, KFDA)
- 발행 : 2002.05.01
초록
A mouse ear swelling test (MEST) has been developed as an alternative to guinea pig models for contact sensitization potential. However, the MEST relies on a quantitative measurement of ear swelling as an endpoint by micrometer. In this study, we aimed to investigate the cell proliferation in ear and lymph node using Bromodeoxyuridine (BrdU) immunohistochemistry as a possible reliable marker for MEST.(omitted)