EVALUATION OF CELL PROLIFERATION IN EAR AND LYMPH NODE USING BRDU IMMUNOHISTOCHEMISTRY FOR MOUSE EAR SWELLING TEST

  • 발행 : 2002.05.01

초록

A mouse ear swelling test (MEST) has been developed as an alternative to guinea pig models for contact sensitization potential. However, the MEST relies on a quantitative measurement of ear swelling as an endpoint by micrometer. In this study, we aimed to investigate the cell proliferation in ear and lymph node using Bromodeoxyuridine (BrdU) immunohistochemistry as a possible reliable marker for MEST.(omitted)

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