Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.82-82
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- 2002
PHOSPHATIDYLINOSITOL 3-KINASE REGULATES NUCLEAR TRANSLOCATION OF Nrf2 THROUGH ACTIN REARRANGEMENT
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Kim, Sang-Geon
(College of Pharmacy, Seoul National University)
;
- Kang, Keon-Wook (College of Pharmacy, Seoul National University) ;
- Lee, Seung-Jin (College of Pharmacy, Seoul National University) ;
- Park, Jeong-Weon (College of Pharmacy, Seoul National University) ;
- Kim, Hye-Jung (College of Pharmacy, Seoul National University)
- Published : 2002.05.01
Abstract
Expression of phase II detoxifying genes is regulated by Nrf2-mediated antioxidant response element (ARE) activation. We previously showed that phosphatidylinositol 3-kinase (PI3-kinase) plays an essential role in ARE-mediated rGSTA2 induction by oxidative stress.(omitted)