Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.80-80
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- 2002
ET-18-O-$CH_3$ INDUCED APOPTOSIS IN H-RAS TRANSFORMED HUMAN BREAST EPITHELIAL CELLS THROUGH UP-REGULATION OF CYCLOOXYGENASE-2
- Na, Hye-Kyung (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- Published : 2002.05.01
Abstract
Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in response to a variety of cytokines. The presence of oncogenic ras has been associated with sustained induction of COX-2, which confers resistance to apoptosis. Contrary to the above notion, we found that MCF10A-ras cells treated with an anti-tumor agent, ET-18-O-