Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2002.05a
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- Pages.79-79
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- 2002
POLYCHLORINATED BIPHENYLS INDUCE ARYL HYDROCARBON RECEPTOR-INDEPENDENT APOPTOSIS OF MOUSE SPLEEN CELL
- Jeon, Young-Jin (College of Medicine University of Chosun) ;
- Youk, Eun-Soo (KRIBB) ;
- Lee, Sang-Han (KRIBB) ;
- Jaehong Suh (Dept. of Biological Sciences, KAIST) ;
- Na, Yong-Joo (Dept. of Biological Sciences, KAIST) ;
- Kim, Hwan-Mook (KRIBB)
- Published : 2002.05.01
Abstract
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, and many of their toxic effects, including their immunotoxicities, are mediated by the activation of aryl hydrocarbon receptor (AhR). We previously reported that Aroclor 1254, one of the most widely used PCB mixtures, increased DNA fragmentation in mouse spleen cells, suggesting that apoptosis was correlated with the immunotoxicity of PCB (Yoo et al., 1997).(omitted)