한국환경독성학회:학술대회논문집 (Proceedings of the Korea Society of Environmental Toocicology Conference)
- 한국환경독성학회 2002년도 추계국제학술대회
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- Pages.165-165
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- 2002
The Sca I RFLP of Atrial Natriuretic Peptide Gene in Koreans
- Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
- Bae, Joon-Seol (Seoulin Bioscience Institute) ;
- Kim, Ki-Tae (Seoulin Bioscience Institute) ;
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Lee, Kang-Oh
(Department of Life Science, Sahmyook University)
- 발행 : 2002.10.01
초록
Hypertension is considered to be caused by a complicated combination of genetic and environmental factors. Atrial natriuretic peptide (ANP) has been to suppress renin activity and inhibit the synthesis and release of aldosterone. Therefore, Abnormalities of this peptide caused by genetic variation may be influence the blood pressure. The aim of present study was to examine the relationship between hypertension and Sca I RFLP of ANP gene in Korean population. The genotype distribution of this RFLP was significantly different between normotensives and hypertensives (P<0.05). However, this genetic marker was not significantly associated with any anthropometric parameters or plasma lipid concentrations in our study group. Therefore, our result suggest that Sca I RFLP of ANP gene may be useful as genetic marker in the ethiology of hypertension in Korean population, independent of any cardiovascular risk. factors studied.