Proceedings of the Korean Society of Embryo Transfer Conference (한국수정란이식학회:학술대회논문집)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Genetic Reprogramming after Somatic Cell cloning

  • Tian, X.Cindy (Center for Regenerative Biology/Department of Animal Science, University of Connecticut) ;
  • Xu, Jie (Center for Regenerative Biology/Department of Animal Science, University of Connecticut) ;
  • Xue, Fei (Center for Regenerative Biology/Department of Animal Science, University of Connecticut) ;
  • Kubota, Chikara (Center for Regenerative Biology/Department of Animal Science, University of Connecticut) ;
  • Du, Fuliang (Center for Regenerative Biology/Department of Animal Science, University of Connecticut) ;
  • Yang, Xiangzhong (Center for Regenerative Biology/Department of Animal Science, University of Connecticut)
  • Published : 2002.11.01
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Abstract

Cloning by nuclear transfer in mammals using somatic cells has enormous potential applications. However, somatic cloning has been inefficient in all species in which NT is successful. High abortion and fetal death rates have been observed. These developmental defects have been attributed to incomplete nuclear reprogramming by the somatic cloning process. In this review, we will discuss studies conducted in our labs to understand the nuclear reprogramming process.

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