한국의학물리학회:학술대회논문집 (Proceedings of the Korean Society of Medical Physics Conference)
- 한국의학물리학회 2002년도 Proceedings
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- Pages.341-344
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- 2002
Improved Perfusion Contrast and Reliability in MR Perfusion Images Using A Novel Arterial Spin Labeling
- Jahng, Geon-Ho (MR Unit, VA Medical Center, University of California-San Francisco) ;
- Xioaping Zhu (MR Unit, VA Medical Center, University of California-San Francisco) ;
- Gerald Matson (MR Unit, VA Medical Center, University of California-San Francisco) ;
- Weiner, Michael-W (MR Unit, VA Medical Center, University of California-San Francisco) ;
- Norbert Schuff (MR Unit, VA Medical Center, University of California-San Francisco)
- 발행 : 2002.09.01
Abstract
Neurodegenerative disorders, like Alzheimer's disease, are often accompanied by reduced brain perfusion (cerebral blood flow). Using the intrinsic magnetic properties of water, arterial spin labeling magnetic resonance imaging (ASLMRI) can map brain perfusion without injection of radioactive tracers or contrast agents. However, accuracy in measuring perfusion with ASL-MRI can be limited because of contributions to the signal from stationary spins and because of signal modulations due to transient magnetic field effects. The goal was to optimize ASL-MRI for perfusion measurements in the aging human brain, including brains with Alzheimer's disease. A new ASL-MRI sequence was designed and evaluated on phantom and humans. Image texture analysis was performed to test quantitatively improvements. Compared to other ASL-MRI methods, the newly designed sequence provided improved signal to noise ratio improved signal uniformity across slices, and thus, increased measurement reliability. This new ASL-MRI sequence should therefore provide improved measurements of regional changes of brain perfusion in normal aging and neurodegenerative disorders.