Proceedings of the Korean Society of Medical Physics Conference (한국의학물리학회:학술대회논문집)

Korean Society of Medical Physics (한국의학물리학회)
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Comparison of Ictal-Interictal Subtraction and Statistical Parametric Mapping in Patients with Temporal Lobe Epilepsy

  • Rahyeong Juh (Dept. of Biomedical Engineering, The Catholic University of Seoul) ;
  • Taesuk Suh (Dept. of Biomedical Engineering, The Catholic University of Seoul) ;
  • Kim, Jaeseung (Dept. of Nuclear Medicine, Asan Medical Center) ;
  • Daehyuk Moon (Dept. of Nuclear Medicine, Asan Medical Center)
  • Published : 2002.09.01
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Abstract

The aim of this study was investigate the epileptogenic zone in temporal lobe epilepsy (TLE). We evaluated the subtraction image of interictal SPECT from ictal SPECT coregistered to 3-dimensional (3D) MRI, and compared with the normal healthy SPECT using a SPM99. Forty-nine patients with TLE (M:F=28:21, mean age: 33${\pm}$2.1 years) underwent a pairs of ictal and interictal SPECT. We performed subtraction interictal SPECT from ictal SPECT in TLE patients. In addition, using SPM methods and t-statistics, SPECT images of the TLE patients were compared with normal healthy SPECT on a voxel by voxel basis. The voxels with a p-value of less than 0.05, 0.005, 0.001 were considered to be significantly different. The subtraction results by ictal and interictal SPECT coincided with the significant rCBF changes when compare of the normal healthy SPECT using a SPM99. The results suggested that analysis of difference of the two methods using healthy normal SPECT with SPM99 is useful tool in evaluation of seizure focus in epilepsy.

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