Proceedings of the Korean Society of Medical Physics Conference (한국의학물리학회:학술대회논문집)

Korean Society of Medical Physics (한국의학물리학회)
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Absorbed Dose from Large Balloon Filled with Liquid Ho-166

  • Joh, Chul-Woo (Departments of Nuclear Medicine, Ajou University School of Medicine) ;
  • Park, Chan H. (Departments of Nuclear Medicine, Ajou University School of Medicine) ;
  • Lee, Myoung-Hoon (Departments of Nuclear Medicine, Ajou University School of Medicine) ;
  • Yoon, Seok-Nam (Departments of Nuclear Medicine, Ajou University School of Medicine) ;
  • Kim, Mi-Hwa (Departments of Radiation Oncology, Ajou University School of Medicine) ;
  • Jang, Ji-Sun (Department of Radiation Oncology, Saint Mary's Hospital, Catholic University) ;
  • Park, Kyung-Bae (Korea Atomic Energy Research Institute)
  • Published : 2002.09.01
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Abstract

Large balloon angio catheter is used for Percutaneous Transluminal Angioplsty(TPA) of the iliac, femoral and renal arteries as well as after Transjugular Intrahepatic portosystemic shunt(TIPS). The use of angioplasty balloon filled with liquid form of radioisotope reduces the rate of restenosis after PTA. The purpose of this study was to evaluate the absorbed dose to the target vessels from various sized large balloon filled with liquid form of Ho-166-DTPA. Four balloons of balloon dilatation catheters evaluated were 5, 6, 8 and 10 mm in diameter. GafChromic film was used for the estimation of the absorbed dose near the surface of the balloon catheters. Absorbed dose rates are plotted in units of Gy/min/GBq/ml as a function of radial distance in mm from the surface of balloon. The absorbed dose rate was 1.1, 1.6, 2.2 and 2.3 Gy/min/GBq/ml at a balloon surface, 0.3, 0.4, 0.5 and 0.6 Gy/min/GBq/ml at 1 mm depth for various balloon diameter 5, 6, 8 and 10 mm in diameter respectively. The study was conducted to estimate the absorbed doses to the vessels from various sized large balloons filled with liquid form of Ho-166-DTPA for clinical trial of radiation therapy after the PTA. The absorbed dose distribution of Ho-166 appeared to be nearly ideal for vascular irradiation since beta range is very short avoiding unnecessary radiation to surrounding normal tissues.

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