한국감성과학회:학술대회논문집 (Proceedings of the Korean Society for Emotion and Sensibility Conference)

한국감성과학회 (Korean Society for Emotion and Sensibility)
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사상관련전위 P300 요소를 이용한 알츠하이머형 치매의 탐지와 분석

Alzheimer Disease detection and analysis using P300 componenet of ERP in Alzheimer type Dementia

  • 박은혜 (고려대학교 심리학과) ;
  • 이영혁 (고려대학교 심리학과) ;
  • 임재환 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 김종우 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 김현택 (고려대학교 심리학과)
  • 발행 : 2002.11.01
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초록

This study is to develop the Alzheimers disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball paradigm in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P300 components were compared among 4 groups. The relationship between P300 measures and neuro psychological test (K-DRS) scores were evaluated by correlations. The latency of P300 was prolonged in AD and the effects were correlated with the severity of dementia. The P300 amplitude was not affected significantly in AD. Theres no difference between normal aged group and young group. These results suggest that the P300 component is specifically affected by Alzheimer type dementia.

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