한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Chondroitin sulfate and Phelinus linteus mushroom : skin whitening

  • 하배진 (신라대학교신소재생명공학부) ;
  • 황일영 (충남대학교의과대학내과) ;
  • 이창훈 (부산대학교의과대학해부병리학과) ;
  • 정영기 (동의대학교자연과학대학미생물학과) ;
  • 강환열 (아마란스화장품)
  • Published : 2001.11.07
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Abstract

This study was conducted to develop a new biomaterial to be used for skin whitening. The melanin elimination effect of chondroitin sulfate and phelinus linteus mushroom in rabbit back skin were evaluated. Rabbit dorsum was exposed to chronic UV irradiation(320nm) once daily for 30 days after initial melanin injection (100mg/kg). And then, chondroitin sulfate and phelinus linteus mushroom at dose of 0.7g for 30days were applied on the zone. The dorsal skin was histologically examined. Furthermore, we investigated free-radical extinction effect, antioxidation and tyrosinase activity inhibition effects. The histological study indicated that chondroitin sulfate and phelinus linteus mushroom decreasd melanine pigment significantly. As a result, chondroitin sulfate and phelinus linteus mushroom have a remarkable effect on the skin whitening by melanin elimination.

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