Mutation Spectrum of 1, 2-Dibromo-3-chloropropane, an Endocrine Disruptor, in the lacI Transgenic Big $\textrm{Blue}^{(R)}$ Rat2 Fibroblast Cell Line.

  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Chai, Young-Gyu (Department of Biochemistry and molecular Biology, Hanyang University) ;
  • Lee, Kilchul (National Institute of Environmental Researc) ;
  • Kyounghee Oh (National Institute of Environmental Researc) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
  • 발행 : 2001.05.01

초록

1,2-Dibromo-3-chloropropane (DBCP), a soil fumigant against nematodes, is a genotoxic carcinogen and also is classified by World Wildlife Fund as endocrine disruptors. DBCP has been extensively studied on genotoxicity, carcinogenicity, and damage in male reproductive-related organs. However, information on precise mechanism of mutagenesis and carcinogenesis of DBCP is yet unknown. (omitted)

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