Reactive Oxygen Species Mediates High Glucose-induced Fibronectin Synthesis in Human Peritoneal Mesothelial Cells

  • Hunjoo Ha (Hyonam Kidney Laboratory, Soon Chun Hyang University) ;
  • Yu, Mi-Ra (Hyonam Kidney Laboratory, Soon Chun Hyang University) ;
  • Lee, Hi-Bahl (Hyonam Kidney Laboratory, Soon Chun Hyang University)
  • 발행 : 2001.06.01

초록

We have recently demonstrated that high glucose (50 mM D-glucose) upregulates fibronectin mRNA expression and protein synthesis by human peritoneal mesothelial cells (HPMC) through activation of protein kinase C (PKC) and suggested that this may lead to progressive peritoneal fibrosis during a long-term peritoneal dialysis (PD) using glucose as an osmotic agent.(omitted)

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