Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2001.06a
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- Pages.65-65
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- 2001
Reactive Oxygen Species Mediates High Glucose-induced Fibronectin Synthesis in Human Peritoneal Mesothelial Cells
- Hunjoo Ha (Hyonam Kidney Laboratory, Soon Chun Hyang University) ;
- Yu, Mi-Ra (Hyonam Kidney Laboratory, Soon Chun Hyang University) ;
- Lee, Hi-Bahl (Hyonam Kidney Laboratory, Soon Chun Hyang University)
- Published : 2001.06.01
Abstract
We have recently demonstrated that high glucose (50 mM D-glucose) upregulates fibronectin mRNA expression and protein synthesis by human peritoneal mesothelial cells (HPMC) through activation of protein kinase C (PKC) and suggested that this may lead to progressive peritoneal fibrosis during a long-term peritoneal dialysis (PD) using glucose as an osmotic agent.(omitted)
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