Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Mechanism of Redox- and Metal-dependent Modulation of RsrA, an Anti-sigma Factor for Redox-dependent Regulation of Thioredoxin Operons in Streptomyces coelicolor

  • Bae, Jae-Bum (Laboratory of Molecular Microbiology, School of Biological Sciences, Seoul National University) ;
  • Park, Ju-Hong (Laboratory of Molecular Microbiology, School of Biological Sciences, Seoul National University) ;
  • Roe, Jung-Hye (Laboratory of Molecular Microbiology, School of Biological Sciences, Seoul National University)
  • Published : 2001.06.01
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Abstract

SigR ($\sigma$$\^$R/) is a sigma factor responsible for inducing the thioredoxin system in response to oxidative stress in Streptomyces coelicolor. RsrA specifically binds to $\sigma$$\^$R/ and inhibits $\sigma$$\^$R/-directed transcription under reducing conditions. Exposure to H$_2$O$_2$ or thiol-specific oxidant diamide dissociates $\sigma$$\^$R/-RsrA complex. RsrA contains 7 cysteine residues in 105 total amino acid residues.(omitted)

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