Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Characterization of Voltage-Sensitive Calcium Channels and Insulin Secretion and the effect of 4,4'-Dichlorobiphenyl in RINm5f cells

  • Lee, Ihn-Soon (Dept. of Life Science, Pohang University of Science and Technology) ;
  • Hur, Eun-Mi (Dept. of Life Science, Pohang University of Science and Technolog) ;
  • Sungkwon Chung (Dept. of Physiology, Sungkyunkwan University School of Medicin) ;
  • Kim, Kyong-Tai (Dept. of Life Science, Pohang University of Science and Technology)
  • Published : 2001.06.01
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Abstract

Opening of $Ca^{2＋}$ -channels represents the final common pathway for insulin secretion in pancreatic beta-cells and related cell lines. We investigated voltage-sensitive calcium channels (VSCCs) and insulin secretion in RINm5F, an insulinoma cell line derived from rat pancreatic beta-cells. Several types of VSCCs were identified in RINm5f cells： dihydropyridine-sensitive L-type, $\omega$-conotoxin GVIA-sensitive N-type, $\omega$-agatoxin IVA-sensitive P-type channels, and $\omega$-conotoxin MVIIC sensitive Q-type channels.(omitted)

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