Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Effects of Cofilin and PMA on $NA^+-K^+$ Pump Current in Guinea- pig Ventricular Myocytes

  • Lee, So-Young (Department of Life Science, Pohang University of Science and Technology) ;
  • Jaehoon Jung (College of Pharmacy, Center of Cell Signaling Research and Division of Molecular Life Science, Ewha Woman′s University) ;
  • Lee, Chin O. (Department of Life Science, Pohang University of Science and Technolog) ;
  • Lee, Kyunglim (College of Pharmacy, Center of Cell Signaling Research and Division of Molecular Life Science, Ewha Woman′s University)
  • Published : 2001.06.01
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Abstract

The Na$^{＋}$-K$^{＋}$ pump, a plasma membrane Na$^{＋}$-K$^{＋}$ ATPase is plays a key role in the regulation and maintenance of Na$^{＋}$ and $K^{＋}$ ion concentration gradients across cell membranes. This enzyme pumps three Na$^{＋}$ out of and two $K^{＋}$ into the cell against their electrochemical gradient by utilizing the energy derived from ATP. Therefore, the Na$^{+}$-K$^{+}$ pump generates a net outward electrical current.(omitted)ted)

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