Effects of Cofilin and PMA on $NA^+-K^+$ Pump Current in Guinea- pig Ventricular Myocytes

  • Lee, So-Young (Department of Life Science, Pohang University of Science and Technology) ;
  • Jaehoon Jung (College of Pharmacy, Center of Cell Signaling Research and Division of Molecular Life Science, Ewha Woman′s University) ;
  • Lee, Chin O. (Department of Life Science, Pohang University of Science and Technolog) ;
  • Lee, Kyunglim (College of Pharmacy, Center of Cell Signaling Research and Division of Molecular Life Science, Ewha Woman′s University)
  • Published : 2001.06.01

Abstract

The Na$^{+}$-K$^{+}$ pump, a plasma membrane Na$^{+}$-K$^{+}$ ATPase is plays a key role in the regulation and maintenance of Na$^{+}$ and $K^{+}$ ion concentration gradients across cell membranes. This enzyme pumps three Na$^{+}$ out of and two $K^{+}$ into the cell against their electrochemical gradient by utilizing the energy derived from ATP. Therefore, the Na$^{+}$-K$^{+}$ pump generates a net outward electrical current.(omitted)ted)

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