An Anti-apoptotic Protein Human Survivin is a Direct Inhibitor of Caspase-3 and -7

  • Sejeong Shin (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology) ;
  • Oh, Byung-Ha (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology)
  • Published : 2001.06.01

Abstract

Survivin, an apoptosis inhibitor/cell-cycle regulator, is critically required for suppression of apoptosis and ensuring normal cell division in the G2/M phase of the cell cycle. It is highly expressed in a cell cycle-regulated manner and localizes together with caspase-3 on microtubules within centrosomes. Whether survivin is a physiologically relevant caspase inhibitor has been unclear due to the difficulties with obtaining correctly folded survivin and finding right conditions for inhibition assay.(omitted)

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