Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)
- 2001.06a
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- Pages.32-32
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- 2001
Crystal Structure of Helicobacter pylori Urease Reveals an Exquisite Molecular Design Suitable for Surviving Gastric Acid
- Ha, Nam-Chul (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology) ;
- Oh, Byung-Ha (National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science, and Division of Molecular and Life Science, Pohang University of Science and Technology)
- Published : 2001.06.01
Abstract
Helicobacter pylori (Hp), an important etiologic agent in a variety of gastroduodenal diseases, produces a large amount of urease, which is believed to neutralize gastric acid by producing ammonia for the survival of the bacteria. Up to 30％ of the enzyme is associated with the surface of intact cells by lysis of neighboring bacteria. However, the role of the external enzyme has been a subject of controversy, because the enzyme is irreversibly inactivated below pH 5.(omitted)
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