Proceedings of the Korean Society of Veterinary Pathology Conference (한국수의병리학회:학술대회논문집)

Korean Society of Veterinary Pathology (한국수의병리학회)
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Modification of Radiation Response in Mice by Panax ginseng and Diethyldithiocarbamate

  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Son, Chang-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Nah, Seung-Yeol (College of Veterinary Medicine, Chonnam National University) ;
  • Jo, Sung-Kee (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Byun, Myung-Woo (Food Irradiation Team, Korea Atomic Energy Research Institute) ;
  • Shin, Dong-Ho (College of Veterinary Medicine, Chonnam National University)
  • Published : 2001.09.01
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Abstract

We performed this study to determine the effect of Panax ginseng and its fractions on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of $\gamma$-irradiation. The radioprotective effect of ginseng was compared with the effect of diethyldithiocarbamate (DDC). Ginseng administration before irradiation protected the jejunal crypts (p<0.005), increased the formation of endogenous spleen colony (p<0.005) and reduced the frequency of radiation-induced apoptosis (p<0.005). (omitted)

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