CHLOROPHYLLIN REDUCES URINARY LEVELS OF A CARCINOGEN-DNA ADDUCT BIOMARKER IN A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

  • PatriciaEgner (Johns Hopkins University Bloomberg School of Public Health) ;
  • JinBingWang (Qidong Liver Cancer Institute, Qidong, Jiangsu Provinc) ;
  • YuanRongZhu (Qidong Liver Cancer Institute, Qidong, Jiangsu Provinc) ;
  • BaoChuZhang (Qidong Liver Cancer Institute, Qidong, Jiangsu Provinc) ;
  • YanWu (Qidong Liver Cancer Institute, Qidong, Jiangsu Provinc) ;
  • QiNanZhang (Qidong Liver Cancer Institute, Qidong, Jiangsu Provinc) ;
  • GengsunQian (Shanghai Cancer Institut) ;
  • ShuangYuanKuang (Shanghai Cancer Institut) ;
  • StephenGange (Johns Hopkins University Bloomberg School of Public Health) ;
  • LisaJacobson (Johns Hopkins University Bloomberg School of Public Health) ;
  • KathyHelzlsouer (Johns Hopkins University Bloomberg School of Public Health) ;
  • GeorgeBailey (Oregon State University) ;
  • Johngroopman (Johns Hopkins University Bloomberg School of Public Health) ;
  • ThomasKensler (Johns Hopkins University Bloomberg School of Public Health)
  • Published : 2001.10.01

Abstract

Residents of Qidong, Peoples Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated with aflatoxins. Chlorophyllin, a mixture of semi-synthetic, water-soluble derivatives of chlorophyll that is used as a food colorant and over-the-counter medicine, has been shown to be an effective inhibitor of aflatoxin hepatocarcinogenesis in animal models.(omitted)

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