한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.202-202
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- 2001
ESTABLISHMENT OF BIOASSAY TO DETECT ESTROGENIC FLAVONOIDS USING STABLE MCF-7-ERE CELL AND MCF-7 CELL PROLIFERASTION ASSAY
- Joung, Ki-Eun (College of pharmacy, Ewha Womans University) ;
- Kim, Yeo-Woon (College of pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of pharmacy, Ewha Womans University)
- 발행 : 2001.10.01
초록
Stable MCF-7-ERE cells, in which pERE-Luc reporter gene has been stably integrated into the genome of the MCF-7 cells, were used to detect the estrogenic activity of various dietary flavonoids.in either pure chemical or mixtures. Estradiol (E2) induced luciferase activity in dose dependent manner and this activity was inhibited by tamoxifen (Tam) concomitant treatment.(omitted)
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