Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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STEREOSELECTIVE METABOLISM AND INHIBITION OF LANSOPRAZOLE ENANTIOMERS ON HUMAN LIVER CYPs.

  • Kim, Kyung-Ah (Department of Pharmacology, Inje University College of Medicine) ;
  • Yoon, Young-Ran (Department of Pharmacology, Inje University College of Medicin) ;
  • Shin, Jae-Gook (Department of Pharmacology, Inje University College of Medicine)
  • Published : 2001.10.01
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Abstract

Stereoselective metabolism and inhibitory potential of lansoprazole enantiomers were evaluated from the incubational studies of human liver microsomes and eDNA-expressed CYP isoforms in vitro. The formation of lansoprazole sulfone from both enantiomers appeared to be catalyzed by single and low affinity enzyme. Lansoprazole 5-hydroxylation, however, appeared to be mediated by two kinetically distinct CYP enzymes.(omitted)

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