TOXIC MECHANISM OF ATRAZINE IN TRANSGENIC MUTAGENESIS SYSTEM USING BIG BLUE$\circledR$ RAT2 lacI TRANSGENIC FIBROBLASTS AND HORMONAL DISTURBANCES IN VITRO

Atrazine, one of herbicide widely used in agriculture, is classified as a possible human carcinogen (2B group) that may cause breast and ovarian cancers by IARC, and is known as an endocrine disruptor. Atrazine has been subjected to broad ranges of genotoxicity tests with predominantly negative results, but reported conflicting results across two or more independent tests as well. This fact indicates that a more comprehensive genotoxicity assessment needs for atrazine.(omitted)