Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.182-182
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- 2001
GENOTOXICITY STUDY OF SOPHORICOSIDE IN BACTERIAL AND MAMMALIAN CELL SYSTEM
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science ＆ Technology) ;
- Kim, Yun-Hwa (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Park, Hyo-Joung (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Gil, Ji-Suk (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ) ;
- Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ) ;
- Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam Natl. Univ) ;
- Park, Jong-Bum (Sam-A Pharmaceutical Co.,) ;
- Kim, Tae-Hwam (Sam-A Pharmaceutical Co.,) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science ＆ Technology)
- Published : 2001.10.01
Abstract
Sophoricoside was isolated as the inhibitor of IL-5 bioactivity from Sophora japonica (Leguminosae). It has been reported to have an anti-inflammatory effect on rat paw edema model. To develope as an anti-allergic drug, genotoxicity of sophoricoside was investigated in bacterial and mammalian cell system such as Ames bacterial test, chromosomal aberration assay and single cell gel electrophoresis (Comet) assay.(omitted)
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