한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.181-181
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- 2001
MUTATION SPECTRUM OF 1,2-DIBROMO-3-CHLOROPROPANE, AN ENDOCRINE DISRUPTOR, IN THE lacI TRANSGENIC BIG BLUE$\circledR$ RAT2 FIBROBLAST CELL LINE
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Chai, Young-Gyu (Department of Biochemistry and molecular Biology, Hanyang University) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
- 발행 : 2001.10.01
초록
1,2-Dibromo-3-chloropropane (DBCP), a soil fumigant against nematodes, is a genotoxic carcinogen and also is classified by World Wildlife Fund as endocrine disruptors. DBCP has been extensively studied on genotoxicity, carcinogenicity, and damage in male reproductive-related organs. However, information on precise mechanism of mutagenesis and carcinogenesis of DBCP is yet unknown. Thus the mutation spectrum and mechanism of DBCP was determined in lacI transgenic Big Blu
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