Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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MUTAGENICITY TESTS OF A NEW CEPHALOSPORIN ANTIBIOTIC AGENT, IDC-7181

  • Zheng, Mei-Shu (College of Veterinary Medicine, Chungbuk National University) ;
  • Sin, Ji-Soon (College of Veterinary Medicine, Chungbuk National University) ;
  • Kwon, Young-Bang (College of Veterinary Medicine, Chungbuk National University) ;
  • Nam, Sang-Yoon (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University)
  • Published : 2001.10.01
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Abstract

The mutagenic potency of a new antibiotics, IDC- 7181, was evaluated using the mutagenicity tests including Ames, chromosome aberration and micronucleus tests. In bacterial reversion assay, IDC-7181 did not show any mutagenic response in the absence or presence of S9 mixture with Salmonella typhimurium TA98, TAlOO, TA1535 and TA1537 and E. coli WP2uvrA-(100, 50, 25, 12.5 and 6.25 $\mu\textrm{g}$/plate).(omitted)

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