Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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GESTATIONAL EXPOSURE TO NONYLPHENOL CAUSE PRECOCIOUS MAMMARY GLAND DEVELOPMENT IN FEMALE RATS

  • Moon, Hyun-Ju (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Hyung-Sik (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Shin, Jae-Ho (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Kang, Il-Hyun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Kim, Tae-Sung (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Suzanne. E. Fenton (NHEERL, EP) ;
  • Han, Soon-Young (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2001.10.01
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Abstract

This experiment tested whether in utero and lactational exposure to 4-nonylphenol (NP) alters mammary gland differentiation in the female offspring rat. Pregnant Sprague Dawley rats were administered NP (l0, 100 mg/kg), atrazine (l00 mg/kg), pesticide demonstrating antiestrogenic activity in mammary gland development, or vehicle (0.5% methyl cellulose) by oral gavage from gestation day 15-19.(omitted)

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