Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.174-174
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- 2001
TOXICITY TEST OF NEW SOLUBILIZER FOR PACLITAXEL IN BEAGLE DOG
- Kim, Yeo-Woon (College of pharmacy, Ewha Womans University) ;
- Min, Kyung-Nan (College of pharmacy, Ewha Womans University) ;
- Syrie Pang (College of pharmacy, Ewha Womans University) ;
- Song, Hye-Weon (College of pharmacy, Ewha Womans University) ;
- Lee, Min-Jae (College of pharmacy, Ewha Womans University) ;
- Lee, Mi-Suk (College of pharmacy, Ewha Womans University) ;
- Kim, Jong-Jae (College of pharmacy, Ewha Womans University) ;
- Sheen, Yhun-Yhong (College of pharmacy, Ewha Womans University)
- Published : 2001.10.01
Abstract
Paclitaxel is currently administered i.v. as a slow infusion of a solution of the drug in an ethanol: cremophor EL: saline admixture. However, poor solubilization and toxicity are associated with this drug therapy. We have tried to develop a new surfactant for paclitaxel to improve efficacy and reduce toxicity of solubilizer.(omitted)
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