한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

FOUR-WEEK REPEATED INTRAMUSCULAR TOXICITY STUDIES OF A NEW TSUTSUGAMUSm VACCINE, MBRI-98305R IN BEAGLE DOGS

  • Ji, Hyeong-Jin (College of Veterinary Medicine, Chungbuk National University) ;
  • Roh,Yong-Woo (College of Veterinary Medicine, Chungbuk National University) ;
  • Sin, Ji-Soon (College of Veterinary Medicine, Chungbuk National University) ;
  • Jung, Eun-Yong (College of Veterinary Medicine, Chungbuk National University) ;
  • Zhang, Hu-Song (College of Veterinary Medicine, Chungbuk National University) ;
  • Huang, Zai-Zhi (College of Veterinary Medicine, Chungbuk National University) ;
  • Zheng, Mei-Shu (College of Veterinary Medicine, Chungbuk National University) ;
  • Choi, Ehn-Kyung (College of Veterinary Medicine, Chungbuk National University) ;
  • Kim, Dae-Joon (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University)
  • 발행 : 2001.10.01
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초록

This study was designed to evaluate a repeated dose toxicity of a new tsutsugamushi vaccine, MBRI-98305R in 4-month-old beagle dogs. Animals were intramuscularly injected with dosages of 283, 56.6, 14.15 and 0 $\mu\textrm{g}$/kg everyday for 4 weeks, respectively. There were no dose-related statistical significant changes in clinical signs, body weight changes, food or water consumption, opthalmoscopy, hematological findings and biochemical examination of all animals treated with MBRI-98305R.(omitted)

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