CELL CYCLE ARREST AND INDUCTION OF APOPTOSIS BY NOVEL CDK INHIBITOR IS ASSOCIATED WITH $p161^{NK4A}$ UP-REGULATION IN HUMAN PROMYELOCYTIC LEUKEMIA CELLS

  • Park, Bu-Young (Department of Molecular Biology and Pharmacology, C&C Research Laboratories) ;
  • Kim, Min-Kyoung (Department of Molecular Biology and Pharmacology, C&C Research Laboratorie) ;
  • Kim, Hak-Yup (Department of Medical Genetics, College of Medicine, Hanyang University) ;
  • Cho, Youl-Hee (Department of Medical Genetics, College of Medicine, Hanyang University) ;
  • Lee, Chul-Hoon (Department of Medical Genetics, College of Medicine, Hanyang University)
  • Published : 2001.10.01

Abstract

MCS-5A, novel Cdk inhibitor, has been reported that it has exerted cell cycle arrest action and apoptotic effect to the human promyelocytic leukemias cell. The purpose of this study is to verify these effects of MCS-5A on human promyelocytic leukemia (HL-60) cells and to clarify the action of mechanism on MCS-5A-inducing apoptosis.(omitted)

Keywords