Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.147-147
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- 2001
DEPRENYL INHIBITS POTENTIATED ARSENIC-INDUCED CYTOTOXICITY VIA THE INHIBITION OF C-JUN N- TERMINAL KINASE ACTIVATION
- Park, Jeong-Weon (College of Pharmacy, Seoul National University) ;
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Kim, Sang-Geon
(College of Pharmacy, Seoul National University)
- Published : 2001.10.01
Abstract
A previous study showed that sulfur amino acid deprivation (SAAD) potentiated cytotoxicity induced by arsenic (As) and that activation of ERKl/2, p38 kinase and JNK1 was responsible for the potentiation of As toxicity. In the present study, we found for the first time that deprenyl a selective monoamine oxidase B inhibitor prevented potentiation of As toxicity by SAAD in a dose-dependent manner.(omitted)
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