Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.143-144
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- 2001
L-ASCORBIC ACID AND ARSENIC TRIOXIDE SYNERGISTICALLY REPRESS CONSTITUTIVE ACTIVATION OF NF- $\textsc{k}$ B AND COX-2 EXPRESSION IN HUMAN ACUTE PROMYELOCYTIC LEUKEMIA, HL-60
- Han, Seong-Su (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Lee, Sook-J. (Samsung Medical Center, and Sungkyunkwan University School of Medicin) ;
- Chung, Seung-Tae (Department of Immunotoxicology, Korea Food and Drug Administratio) ;
- Eom, Juno-H. (Department of Immunotoxicology, Korea Food and Drug Administratio) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University) ;
- Park, Hye-K. (Samsung Medical Center, and Sungkyunkwan University School of Medicin) ;
- Park, Mary-H. (Samsung Medical Center, and Sungkyunkwan University School of Medicin) ;
- Kim, Won-S. (Samsung Medical Center, and Sungkyunkwan University School of Medicin) ;
- Kim, Ki-Hyun (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Park, Keun-Chil (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Kim, Jhin-Gook (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Yang, Jung-Hyun (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Yoon, Sung-S (Samsung Medical Center, and Sungkyunkwan University School of Medicine) ;
- Neil H.Riordan (Aidan Incorporated) ;
- HughD.Riordan (The Center for Improvement of Human Functioning International) ;
- BruceF.Kimler (University of Kansas Medical Center) ;
- Park, Chan-H. (Samsung Medical Center, and Sungkyunkwan University School of Medicine)
- Published : 2001.10.01
Abstract
Eukaryotic nuclear transcription factor, NF-B and cyclooxygenase-2 (COX-2) has been implicated in pathogenesis of many human diseases including tumor and are known to be activated by various external stimuli. Recently, increasing evidences have supported that L-ascorbic acid (LAA) is selectively toxic to some types of tumors at pharmacological concentrations as a prooxidant, rather than antioxidant.(omitted)
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