한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.137-138
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- 2001
CELECOXIB INHIBITS PHORBOL ESTER-INDUCED EXPRESSION OF CYCLOOXYGENASE-2 AND ACTIVATION OF ERKl/2 IN MOUSE SKIN IN VIVO
- Chun, Kyung-Soo (College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (College of Pharmacy, Seoul National University)
- 발행 : 2001.10.01
초록
There has been accumulating evidence for the association of inflammatory tissue damage with the process of cancer development. Cyclooxygenase (COX), an important enzyme involved in mediating the inflammation, catalyzes the formation of prostaglandins (PGs) from arachidonic acid. There are two isoforms of COX, designated as COX-l and COX-2. COX-l is a housekeeping enzyme which is constitutively expressed and is thought to be involved in maintaining physiological functions.(omitted)
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