CELECOXIB INHIBITS PHORBOL ESTER-INDUCED EXPRESSION OF CYCLOOXYGENASE-2 AND ACTIVATION OF ERKl/2 IN MOUSE SKIN IN VIVO

  • Published : 2001.10.01

Abstract

There has been accumulating evidence for the association of inflammatory tissue damage with the process of cancer development. Cyclooxygenase (COX), an important enzyme involved in mediating the inflammation, catalyzes the formation of prostaglandins (PGs) from arachidonic acid. There are two isoforms of COX, designated as COX-l and COX-2. COX-l is a housekeeping enzyme which is constitutively expressed and is thought to be involved in maintaining physiological functions.(omitted)

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