Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
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- Pages.135-136
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- 2001
EFFECTS OF THE SOY ISOFLAVONE GENISTEIN ON COX-2 EXPRESSION AND ACTIVATION OF ERKl/2 INDUCED BY PHORBOL ESTER AND TNF-$\alpha$ IN HUMAN BREAST EPITHELIAL CELL LINE (MCF10A)
- Chung, Myung-Hoon (College of Pharmacy, Seoul National University) ;
- Kim, Jung-Hwan (School of Medicine, Sung-Kyun-Kwan University) ;
- Lee, Seung-Sei (School of Medicine, Sung-Kyun-Kwan University) ;
- Keum, Joo-Seob (School of Medicine, Sung-Kyun-Kwan University) ;
- Surh, Young-Joon (School of Medicine, Sung-Kyun-Kwan University)
- Published : 2001.10.01
Abstract
Genistein has been shown to exert propective effects against chemically induced carcinogenesis in animals as well as malignant transformation in cultured cells, but molecular mechanisms of its chemopreventive or chemoprotective activities remain largely unresolved. In the present sturdy, we have investigated the effects of genistein on induction of cyclooxygenase-2 (COX-2) that plays an important role in the pathophysiology of carcinogenesis as well as in cellular response to inflammatory stimuli.(omitted)
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