PROTECTION EFFECT OF GINSENG EXTRACT AGAINST APOPTOTIC CELL DEATH INDUCED BY 2,2,5,5-TETRACHLOROBIPHENYL IN NEURONAL SK-N-MC CELLS

  • Lee, Ji-Young (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Kim, Jae-Won (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Song, Ji-Eun (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Kim, Soo-Jung (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Chung, Weon-Gu (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Kim, Yong-Hoon (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Lee, Bo-Ram (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Kim, Jin-Hee (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Choi, Young-Keun (Department of Biochemistry and Health Sciences, Changwon National Univ.) ;
  • Joo, Woo-Hong (Department of Biology, College of Natural Sciences, Changwon National Univ.) ;
  • Cho, Yong-Kweon (Department of Biochemistry and Health Science,Changwon National Univ.) ;
  • Moon, Ja-Young (Department of Biochemistry and Health Science,Changwon National Univ.)
  • Published : 2001.10.01

Abstract

Oxidative stress plays an important role in the pathological process of neurodegenerative diseases. Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. Our previous studies showed that 2,2',5,5'-TetracWorobiphenyl (PCB 52) induced apoptotic death in human neuronal SK-N-MC cells, which was demonstrated on gel electrophoresis by visualization of the proteolytic cleavages of $\beta$-catenin and poly (ADP-ribose) polymerase (PARP) and of the production of characteristic ladder patterns of DNA fragmentation.

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