한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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SELENITE SUPPRESSES HYDROGEN PEROXIDE-INDUCED CELL APOPTOSIS THROUGH INHIBITION OF ASK1 AND ACTIVATION OF PI3-K/AKT PATHWAYS

  • Yoon, Sang-Oh (Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Chung, An-Sik (Dept. of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • 발행 : 2001.10.01
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초록

The relationship between selenium and signal molecules is not well elucidated yet. It was found that physiological concentration of selenite, less than 3 $\mu$M, reduced ASKl activity and induced of PI3-Kinase/Akt pathways in HT1080 cells. Duration of these signal molecules by selenite was much longer than that by growth factors and other stresses. The longer duration time of these signal molecules may be important to maintain normal functions against stresses.(omitted)

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