Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PROTECTION OF DNA BY SCUTELLARlA BAICALENSIS IN HL-60 CELLS EXPOSED TO $\gamma$-RAYS; ANALYSED BY MICRONUCLEI FORMATION AND SINGLE CELL GELL ELECTROPHORESIS

  • Heon Oh (Radiation Food Science ＆ Biotechnology Team, Korea Atomic Energy Research Institute) ;
  • Park, Hae-Ran (Radiation Food Science ＆ Biotechnology Team, Korea Atomic Energy Research Institut) ;
  • Ham, Yeon-Ho (Radiation Food Science ＆ Biotechnology Team, Korea Atomic Energy Research Institut) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Jo, Sung-Kee (Radiation Food Science ＆ Biotechnology Team, Korea Atomic Energy Research Institute)
  • Published : 2001.10.01
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Abstract

In the present study, the protective effect of Scutellaria baicalensis against DNA damage in HL-60 cells exposed to $^{60}$ Co ${\gamma}$-rays was evaluated using micronuclei formation and alkaline single cell gel electrophoresis (SCGE, comet assay). The frequency of micronuclei was decreased in groups treated with water extract (P＜0.01), polysaccaride fraction (P＜0.01) and methanol fraction (P＜0.01) before/after exposure to 200 cGy of ${\gamma}$-rays.(omitted)

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