한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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- Pages.95-96
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- 2001
MUTAGENICITY AND ANTIMUTAGENICITY OF CATECHIN AND TANNINS FROM THE BARK OF HAMAMELIS VIRGINIANA L. IN HUMAN Hep G2 CELLS
- Sundermann, Volker-Mersch (Department of Toxicology and Ecotoxicology, University of Trier) ;
- Andreas Dauer (Department of Toxicology and Ecotoxicology, University of Trie) ;
- Evelyne Lhoste (INRA-UEPSD, Domaine de Vilver) ;
- Siegfried Knasmuller (Institute of Cancer Research, University of Vienna)
- 발행 : 2001.10.01
초록
The mutagenic and antimutagenic activities of catechin, hamamelitannin and two proanthocyanidin fractions prepared from the bark of Hamamelis virginia L. - a commonly used medicinal herb - were investigated in a human derived hepatoma (Hep G2) cell line using the single cell gel electrophoresis (SCGE, syn. Comet assay) for the detection of DNA-migration. The cells possess different phase I and phase II enzymes involved in the biotransformation of xenobiotics.(omitted)
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