Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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STUDIES ON THE ANTIMUTAGENICITY OF VITAMINS AND NAPHTHOFLAVONES TOWARDS HETEROCYCLIC AMINES

  • Sundermann, Volker-Mersch (Department of Toxicology and Ecotoxicology, University of Trier) ;
  • Rosario Palmieri (Institut of Medical Microbiology and Hygiene, University Hospital of Mannheim, University of Heidelber) ;
  • Saeid Sharifi (Institut of Medical Microbiology and Hygiene, University Hospital of Mannheim, University of Heidelber) ;
  • Richard Gminski (Department of Toxicology and Ecotoxicology, University of Trier)
  • Published : 2001.10.01
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Abstract

Former studies dealing with combined effects caused by chemical compounds in the metabolically competent hepatoma cell line Hep G2 indicated that Hep G2 cells are useful and sensitive indicators for the identification of synergisms of promutagens, comutagens and antimutagens which are relevant in eukryontic (human) cells. In the present study we examined the modulation of DNA damages by the suspected antimutagens ascorbic acid, beta-carotene, alpha-naphthoflavone and beta-naphthoflavone in Hep G2 cells.(omitted)

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