Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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PRE-INITIATION TREATMENT OF INDOLE-3-CARBINOL (I3C) INHIBITS 7,12-DIMETHYLBENZ［a］ANTHRACENE(DMBA)-INDUCED RAT MAMMARY CARCINOGENESIS

  • kang, Jin-Seok (National Institute of Toxicology Research, Korea Food and Drug Administration) ;
  • Ahn, Byeong-Woo (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Lee, Kook-Kyung (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Nam, Ki-Taek (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Che, Jeong-Hwan (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Choi, Mina (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Kim, Ji-Young (National Institute of Toxicology Research, Korea Food and Drug Administratio) ;
  • Kim, Dae-Joong (Structural BioInformatics ＆ Cancer Prevention Laboratory, College of Veterinary Medicine ＆ Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Jang, Dong-Deuk (National Institute of Toxicology Research, Korea Food and Drug Administration) ;
  • Yang, Ki-Hwa (National Institute of Toxicology Research, Korea Food and Drug Administration)
  • Published : 2001.10.01
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Abstract

Indole-3-carbinol (I3C), one component of cruciferous vegetables (the Family of Cruciferae), has been shown to exert chemopreventive effects in liver, colon and mammary tissue, but there has been substantial evidence that consumption of I3C induces tumor promotion in some tissues. Our studies were investigated to examine the modifying effects of I3C in the 7, 12-dimethylbenz［a］anthracene (DMBA) induced rat mammary tumor model.(omitted)

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