Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

CHEMOPREVENTION OF MAMMARY CARCINOGENESIS BY SYNTHETIC ANALOG OF VITAMIN D5.

  • Mehta, Rajendra G. (Department of Surgical Oncology, University of Illinois at Chicago) ;
  • Hussain, Erum (Department of Surgical Oncology, University of Illinois at Chicag) ;
  • Moriarty, Robert M. (Department of Surgical Oncology, University of Illinois at Chicag) ;
  • Mehta, Rajeshwari R. (Department of Surgical Oncology, University of Illinois at Chicag) ;
  • Das Gupta, Tapas K. (Department of Surgical Oncology, University of Illinois at Chicago)
  • Published : 2001.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

In order for vitamin D to be active, it needs to get metabolized to 1, 25 (OH)$_2$D3. This active metabolite of vitamin D induces epithelial cell differentiation and is antiproliferative. However, at the efficacious concentration, the natural ligand for VDR is hypercalcemic and toxic to cells. Therefore, numerous analogs have been synthesized with the hope of generating a compound that retains vitamin D activity and is non-toxic.(omitted)

Keywords