Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2001.10a
- /
- Pages.37-38
- /
- 2001
NEW SELECTIVE AND POTENT INHIBITORS OF HUMAN CYTOCHROM P450 1A FAMILY ENZYMES
- F. Peter Guengerich (Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University) ;
- Chun, Young-Jin (College of Pharmacy, Chungang University) ;
- Kim, Sanghee (Natural Product Research Institute, Seoul National University) ;
-
Kim, Donghak
(Natural Product Research Institute, Seoul National University)
;
- Lee, Sang-Kwang (Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University) ;
- Dong, Mi-Sook (Korea Graduate School of Biotechnology, Korea University) ;
- Ueng, Yune-Fang (National Research Institute of Chinese Medicine)
- Published : 2001.10.01
Abstract
The cytochrome P450 (P450) 1 family (1A1, 1A2, 1B1) is involved in the activation of many pro-carcinogens. Previously we characterized a number of synthetic bi- and polycyclic hydrocarbon acetylenes as selective-mechanism-based inhibitors of recombinent P450s 1A1, 1A2, 1B1 (Shimada et al., Chem. Res. Toxicol., 11, 1048-1056, 1998). We reported that the drug oltipraz is a mechanism-based indicator of P450 1A2 (Lagouet et al. Chem. Res. Toxicol., 13, 245-252, 2000).(omitted)
Keywords