Inhibition of Growth Factor-induced MAP kinase and Akt Activation by NQ304, a 1,4-Naphthoquinone Derivative in Rat Aortic Vascular Smooth Muscle Cells

  • Kim, T-J (College of Pharmacy, Chungbuk National University) ;
  • Hong, J-T (Korea Food and Drug Administration) ;
  • Ryu, C-K (College of Pharmacy, Ewha Womans University) ;
  • Park, Y-S (College of Pharmacy, Chungbuk National University) ;
  • Song, Y-S (College of Pharmacy, Chungbuk National University) ;
  • Yu, M-U (College of Pharmacy, Chungbuk National University) ;
  • Jeon, J-S (College of Pharmacy, Chungbuk National University) ;
  • Jin, Y-R (College of Pharmacy, Chungbuk National University) ;
  • Yun, Y-P (College of Pharmacy, Chungbuk National University)
  • Published : 2001.05.01

Abstract

We recently reported that, 2-chloro-3-(4-hexylphenyI)-amino-l, 4-naphthoquinone(NQ304), a naphthoquinone derivative, had potent inhibitory effects on the platelet aggregation in vitro and thrombosis in vivo. Furthermore, we reported the antiplatelet mechanism of NQ304 by the reduction of the thromboxane A2 formation, inhibition of adenosine triphosphate release and intracellular calcium mobilization.(omitted)

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